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Hypoxia and acidosis: immune suppressors and therapeutic targets
Author(s) -
Damgaci Sultan,
IbrahimHashim Arig,
EnriquezNavas Pedro M.,
PilonThomas Shari,
Guvenis Albert,
Gillies Robert J.
Publication year - 2018
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12917
Subject(s) - hypoxia (environmental) , immune system , vascularity , acidosis , stressor , biology , immunology , medicine , bioinformatics , neuroscience , pathology , chemistry , organic chemistry , oxygen
Summary Due to imbalances between vascularity and cellular growth patterns, the tumour microenvironment harbours multiple metabolic stressors including hypoxia and acidosis, which have significant influences on remodelling both tumour and peritumoral tissues. These stressors are also immunosuppressive and can contribute to escape from immune surveillance. Understanding these effects and characterizing the pathways involved can identify new targets for therapy and may redefine our understanding of traditional anti‐tumour therapies. In this review, the effects of hypoxia and acidosis on tumour immunity will be summarized, and how modulating these parameters and their sequelae can be a useful tool for future therapeutic interventions is discussed.