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The versatility of the CD 1 lipid antigen presentation pathway
Author(s) -
Chancellor Andrew,
Gadola Stephan D.,
Mansour Salah
Publication year - 2018
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12912
Subject(s) - major histocompatibility complex , antigen presentation , antigen , biology , autoimmunity , t cell , antigen processing , antigen presenting cell , immunology , microbiology and biotechnology , mhc class i , computational biology , immune system
Summary The family of non‐classical major histocompatibility complex ( MHC ) class‐I like CD 1 molecules has an emerging role in human disease. Group 1 CD 1 includes CD 1a, CD 1b and CD 1c, which function to display lipids on the cell surface of antigen‐presenting cells for direct recognition by T‐cells. The recent advent of CD 1 tetramers and the identification of novel lipid ligands has contributed towards the increasing number of CD 1‐restricted T‐cell clones captured. These advances have helped to identify novel donor unrestricted and semi‐invariant T‐cell populations in humans and new mechanisms of T‐cell recognition. However, although there is an opportunity to design broadly acting lipids and harness the therapeutic potential of conserved T‐cells, knowledge of their role in health and disease is lacking. We briefly summarize the current evidence implicating group 1 CD 1 molecules in infection, cancer and autoimmunity and show that although CD 1 are not as diverse as MHC , recent discoveries highlight their versatility as they exhibit intricate mechanisms of antigen presentation.