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Autoimmunity and autoimmune co‐morbidities in psoriasis
Author(s) -
Furue Kazuhisa,
Ito Takamichi,
Tsuji Gaku,
Kadono Takafumi,
Nakahara Takeshi,
Furue Masutaka
Publication year - 2018
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12891
Subject(s) - psoriasis , vitiligo , autoimmunity , medicine , immunology , autoimmune thyroiditis , interleukin 17 , dermatology , autoimmune disease , inflammation , thyroiditis , immune system , disease , pathology , antibody
Summary Psoriasis is characterized by widespread scaly erythematous plaques that cause significant physical and psychological burdens for the affected individuals. Accelerated inflammation driven by the tumour necrosis factor‐ α /interleukin‐23/interleukin‐17 axis is now known to be the major mechanism in the development of psoriasis. In addition, psoriasis has an autoimmune nature that manifests as autoreactive T cells and is co‐morbid with other autoimmune diseases, such as autoimmune bullous diseases, vitiligo, alopecia and thyroiditis. In this article, we review the recent topics on autoimmunity and autoimmune co‐morbidities in psoriasis.