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Using immunocompromised mice to identify mechanisms of Zika virus transmission and pathogenesis
Author(s) -
Winkler Clayton W.,
Peterson Karin E.
Publication year - 2018
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12883
Subject(s) - zika virus , pathogenesis , immunology , immune system , biology , transmission (telecommunications) , innate immune system , virology , viral pathogenesis , mechanism (biology) , virus , acquired immune system , sexual transmission , viral replication , human immunodeficiency virus (hiv) , philosophy , microbicide , epistemology , electrical engineering , engineering
Summary Zika virus ( ZIKV ) is responsible for a recent global epidemic that has been associated with congenital brain malformations in fetuses and with Guillain–Barré syndrome in adults. Within the last 2 years, a major effort has been made to develop murine models to study the mechanism of viral transmission, pathogenesis and the host immune response. Here, we discuss the findings from these models regarding the role that the innate and adaptive immune responses have in controlling ZIKV infection and pathogenesis. Additionally, we examine how innate and adaptive immune responses influence sexual and vertical transmission of ZIKV infection as well as how these responses can influence the ability of ZIKV to cross the placenta and to induce damage in the developing brain.