Premium
Dissecting human ILC heterogeneity: more than just three subsets
Author(s) -
Simoni Yannick,
Newell Evan W.
Publication year - 2018
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12862
Subject(s) - innate lymphoid cell , biology , immunology , immune system , cytokine , immunity , phenotype , receptor , transcription factor , inflammation , progenitor cell , progenitor , microbiology and biotechnology , stem cell , gene , genetics
Summary Innate lymphoid cells ( ILC s) have been divided into three distinct groups based on functional capacities, cytokine profiles and transcription factor expression. Studies performed mainly in mice have demonstrated the importance of ILC s in chronic inflammation, infection, allergy and cancer. In this review, we discuss the heterogeneity of human ILC and focus primarily on the taxonomy of human ILC cell subsets and their phenotypical and functional diversity. We summarize recent findings concerning the diversity of ILC s between and within the major subsets [natural killer ( NK) , ILC 1, intra‐epithelial ILC1 (ie ILC 1), ILC 2, ILC 3, lymphoid tissues inducer (LT i) and ILC progenitor (ILCP )], as well as the abundance of each in human tissues. We also discuss the similarities observed between groups of cells in term of receptors expressed and cytokines produced, and how these relate to the pleiotropic properties of each subset.