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The regulation of regulation: interleukin‐10 increases CD 4 + CD 25 + regulatory T cells but impairs their immunosuppressive activity in murine models with schistosomiasis japonica or asthma
Author(s) -
He Lei,
Zhou Sha,
Qi Qianqian,
Chi Ying,
Zhu Jifeng,
Xu Zhipeng,
Wang Xuefeng,
Hoellwarth Jason,
Liu Feng,
Chen Xiaojun,
Su Chuan
Publication year - 2018
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12813
Subject(s) - il 2 receptor , foxp3 , immune system , immunology , biology , regulatory t cell , interleukin 10 , cytokine , transforming growth factor beta , transforming growth factor , microbiology and biotechnology , t cell
Summary CD 4 + CD 25 + Foxp3 + regulatory T (Treg) cells play an important role in maintaining immune homeostasis. Interleukin‐10 ( IL ‐10), a cytokine with anti‐inflammatory capacities, also has a critical role in controlling immune responses. In addition, it is well known that production of IL ‐10 is one of the suppression mechanisms of Treg cells. However, the action of IL ‐10 on Treg cells themselves remains insufficiently understood. In this study, by using a Schistosoma japonicum ‐infected murine model, we show that the elevated IL ‐10 contributed to Treg cell induction but impaired their immunosuppressive function. Our investigations further suggest that this may relate to the up‐regulation of serum transforming growth factor ( TGF ‐ β ) level but the decrease in membrane‐bound TGF ‐ β of Treg cells by IL ‐10 during S. japonicum infection. In addition, similar IL ‐10‐mediated regulation on Treg cells was also confirmed in the murine model of asthma. In general, our findings identify a previously unrecognized opposing regulation of IL ‐10 on Treg cells and provide a deep insight into the precise regulation in immune responses.