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Structural and functional changes to lymph nodes in ageing mice
Author(s) -
Turner Vivian M.,
Mabbott Neil A.
Publication year - 2017
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12727
Subject(s) - germinal center , immune system , follicular dendritic cells , lymphatic system , lymph , cxcl13 , stromal cell , biology , lymph node , immunology , chemokine , macrophage , lymph node stromal cell , dendritic cell , microbiology and biotechnology , b cell , t cell , pathology , antigen presenting cell , cancer research , antibody , medicine , chemokine receptor , biochemistry , in vitro
Summary Lymph nodes ( LN ) are secondary lymphoid organs spread throughout the lymphatic system. They function to filter pathogenic material from the lymphatic fluid to maintain the health of the organism. Subcapsular sinus macrophages ( SCSM ) are among the first‐responders within the LN due to their strategic location within the subcapsular sinus region. These macrophages aid the delivery of immune complexes to B cells and follicular dendritic cells ( FDC ) within the LN . Here we show an increase in SCSM and other macrophage populations within aged LN . However, immune complex uptake by macrophages within LN was not altered with age, nor was immune complex uptake by B cells. LN stromal cell populations, important in immune responses and the localization and survival of leucocytes, were altered in their representation and distribution in aged LN . In particular, FDC regions were decreased in size and had decreased chemokine CXCL 13 expression. Furthermore, the retention of immune complexes by FDC was decreased in aged LN at 24 hr post‐injection. As FDC are important in the maintenance of germinal centre responses, the decreased retention of immune complex in aged LN may contribute to the reduced germinal centre responses observed in aged mice.