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Functional interleukin‐33 receptors are expressed in early progenitor stages of allergy‐related granulocytes
Author(s) -
Tsuzuki Hirofumi,
Arinobu Yojiro,
Miyawaki Kohta,
Takaki Ayako,
Ota Shunichiro,
Ota Yuri,
Mitoma Hiroki,
Akahoshi Mitsuteru,
Mori Yasuo,
Iwasaki Hiromi,
Niiro Hiroaki,
Tsukamoto Hiroshi,
Akashi Koichi
Publication year - 2017
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12667
Subject(s) - immunology , allergic inflammation , interleukin 33 , eosinophil , progenitor cell , innate lymphoid cell , interleukin 5 , innate immune system , cytokine , basophil , inflammation , biology , allergy , mast cell , myelopoiesis , eosinophilia , interleukin 3 , immunoglobulin e , interleukin , microbiology and biotechnology , stem cell , immune system , t cell , antibody , il 2 receptor , asthma
Summary Interleukin‐33 ( IL ‐33) induces T helper type 2 (Th2) cytokine production and eosinophilia independently of acquired immunity, leading to innate immunity‐mediated allergic inflammation. Allergy‐related innate myeloid cells such as eosinophils, basophils and mast cells express the IL ‐33 receptor ( IL ‐33R), but it is still unknown how IL ‐33 regulates allergic inflammation involving these cells and their progenitors. Here, we revealed that the functional IL ‐33R was expressed on eosinophil progenitors (EoPs), basophil progenitors (BaPs) and mast cell progenitors ( MCP s). In the presence of IL ‐33, these progenitors did not expand, but produced a high amount of Th2 and pro‐inflammatory cytokines such as IL ‐9, IL ‐13, IL ‐1 β and IL ‐6. The amount of cytokines produced by these progenitors was greater than that by mature cells. In vivo , IL ‐33 stimulated the expansion of EoPs, but it was dependent upon the elevated serum IL ‐5 that is presumably derived from type 2 innate lymphoid cells that express functional IL ‐33R. These data collectively suggest that EoPs, BaPs and MCP s are not only the sources of allergy‐related granulocytes, but can also be sources of allergy‐related cytokines in IL ‐33‐induced inflammation. Because such progenitors can differentiate into mature granulocytes at the site of inflammation, they are potential therapeutic targets in IL ‐33‐related allergic diseases.

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