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Tacrolimus prevents murine cerebral malaria
Author(s) -
Bao Lam Quoc,
Nhi Dang My,
Huy Nguyen Tien,
Hamano Shinjiro,
Hirayama Kenji
Publication year - 2017
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12661
Subject(s) - tacrolimus , cerebral malaria , plasmodium berghei , malaria , cd8 , immunology , mycophenolate , medicine , plasmodium falciparum , pharmacology , peripheral blood mononuclear cell , biology , transplantation , immune system , in vitro , biochemistry
Summary Tacrolimus and mycophenolate mofetil are immunosuppressants frequently used in human organ transplantation. Tacrolimus is also reported to inhibit Plasmodium falciparum growth in vitro . Here, we report that tacrolimus prevented the death from cerebral malaria of Plasmodium berghei ANKA‐infected C57BL/6J mice, but not their death from malaria due to the high parasitaemia and severe anaemia. The mycophenolate mofetil‐treated mice showed higher mortality from cerebral malaria and succumbed to malaria earlier than tacrolimus‐treated littermates. Tacrolimus attenuated the infiltration of mononuclear cells including pathogenic CD8 + T cells into the brain. It appears to prevent murine cerebral malaria through the inhibition of cerebral infiltration of CD8 + T cells.