Premium
The contribution of the citrate pathway to oxidative stress in Down syndrome
Author(s) -
Convertini Paolo,
Menga Alessio,
Andria Generoso,
Scala Iris,
Santarsiero Anna,
Castiglione Morelli Maria A.,
Iacobazzi Vito,
Infantino Vittoria
Publication year - 2016
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12659
Subject(s) - oxidative stress , carnitine , lipid peroxidation , reactive oxygen species , phenotype , inflammation , transferase , chemistry , oxidative phosphorylation , microbiology and biotechnology , biochemistry , gene , endocrinology , biology , medicine , enzyme
Summary Inflammatory conditions and oxidative stress have a crucial role in Down syndrome ( DS ). Emerging studies have also reported an altered lipid profile in the early stages of DS . Our previous works demonstrate that citrate pathway activation is required for oxygen radical production during inflammation. Here, we find up‐regulation of the citrate pathway and down‐regulation of carnitine/acylcarnitine carrier and carnitine palmitoyl‐transferase 1 genes in cells from children with DS . Interestingly, when the citrate pathway is inhibited, we observe a reduction in oxygen radicals as well as in lipid peroxidation levels. Our preliminary findings provide evidence for a citrate pathway dysregulation, which could be related to some phenotypic traits of people with DS .