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Innate lymphoid cell regulation of adaptive immunity
Author(s) -
Withers David R.
Publication year - 2016
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12639
Subject(s) - acquired immune system , innate lymphoid cell , biology , immunity , innate immune system , immune system , adaptive response , neuroscience , underpinning , homeostasis , immunology , microbiology and biotechnology , genetics , civil engineering , engineering
Summary Innate lymphoid cells ( ILC s) were identified principally as non‐T‐cell sources of key cytokines, able to provide rapid and early production of these molecules in the support of tissue homeostasis, repair and response to infection. As our understanding of these cells has developed, it has become evident that ILC s can impact on lymphocytes through a range of mechanisms. Hence, an exciting area of research has evolved in determining the extent to which ILC s may regulate adaptive immune responses. This review will focus initially on our current understanding of where ILC populations are located and what this means for potential cellular interactions. Mechanisms underpinning such interactions and how they may contribute to controlling adaptive immunity will then be considered.