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Translocation of microbes and changes of immunocytes in the gut of rapid‐ and slow‐progressor Chinese rhesus macaques infected with SIV mac239
Author(s) -
Zhang LinTao,
Tian RenRong,
Zheng HongYi,
Pan GuoQing,
Tuo XiaoYu,
Xia HouJun,
Xia XueShan,
Pang Wei,
Zheng YongTang
Publication year - 2016
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12574
Subject(s) - chromosomal translocation , biology , bacterial translocation , microbiology and biotechnology , virology , genetics , gene
Summary Human/simian immunodeficiency virus ( HIV / SIV ) infection can cause severe depletion of CD 4 + T cells in both plasma and mucosa; it also results in damage to the gut mucosa barrier, which makes the condition more conducive to microbial translocation. In this study, we used SIV ‐infected Chinese rhesus macaques to quantify the extent of microbial translocation and the function of immune cells in the entire gastrointestinal tract and to compare their differences between rapid and slow progressors. The results showed that in the slow progressors, microbial products translocated considerably and deeply into the lamina propria of the gut; the tissue macrophages had no significant differences compared with the rapid progressors, but there was a slightly higher percentage of mucosal CD 8 + T cells and a large amount of extracellular microbial products in the lamina propria of the intestinal mucosa of the slow progressors. The data suggested that although microbial translocation increased markedly, the mucosal macrophages and CD 8 + T cells were insufficient to clear the infiltrated microbes in the slow progressors. Also, therapies aimed at suppressing the translocation of microbial products in the mucosa could help to delay the progression of SIV disease.