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Chrono‐immunology: progress and challenges in understanding links between the circadian and immune systems
Author(s) -
Geiger Sarah S.,
Fagundes Caio T.,
Siegel Richard M.
Publication year - 2015
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12525
Subject(s) - circadian rhythm , immune system , crosstalk , neuroscience , circadian clock , biology , immunity , multitude , immunology , political science , engineering , electronic engineering , law
Summary Development of inflammatory diseases, such as metabolic syndrome and cancer, is prevalent in individuals that encounter continuous disruption of their internal clock. Further, daily oscillations in susceptibility to infection as well as a multitude of other immunological processes have been described. Much progress has been made and various mechanisms have been proposed to explain circadian variations in immunity; yet much is still unknown. Understanding the crosstalk between the circadian and the immune systems will allow us to manipulate clock outputs to prevent and treat inflammatory diseases in individuals at risk. This review briefly summarizes current knowledge about circadian rhythms and their role in the immune system and highlights progress and challenges in chrono‐immunological research.