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Critical roles of co‐activation receptor DNAX accessory molecule‐1 in natural killer cell immunity
Author(s) -
Xiong Peng,
Sang HaiWei,
Zhu Min
Publication year - 2015
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12516
Subject(s) - dnam , biology , immune system , innate immune system , microbiology and biotechnology , receptor , natural killer cell , immunotherapy , immunology , cytotoxic t cell , biochemistry , gene , gene expression , dna methylation , in vitro
Summary Natural killer ( NK ) cells, which can exert early and powerful anti‐tumour and anti‐viral responses, are important components of the innate immune system. DNAX accessory molecule‐1 ( DNAM ‐1) is an activating receptor molecule expressed on the surface of NK cells. Recent findings suggest that DNAM ‐1 is a critical regulator of NK cell biology. DNAM ‐1 is involved in NK cell education and differentiation, and also plays a pivotal role in the development of cancer, viral infections and immune‐related diseases. However, tumours and viruses have developed multiple mechanisms to evade the immune system. They are able to impair DNAM ‐1 activity by targeting the DNAM ‐1 receptor–ligand system. We have reviewed the roles of DNAM ‐1, and its biological functions, with respect to NK cell biology and DNAM ‐1 chimeric antigen receptor‐based immunotherapy.