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Micro RNA s affect dendritic cell function and phenotype
Author(s) -
Smyth Lesley A.,
Boardman Dominic A.,
Tung Sim L.,
Lechler Robert,
Lombardi Giovanna
Publication year - 2015
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12390
Subject(s) - microrna , biology , dendritic cell , microbiology and biotechnology , immune system , function (biology) , antigen presentation , rna , acquired immune system , progenitor cell , phenotype , gene , immunology , t cell , stem cell , genetics
Summary Micro RNA (mi RNA ) are small, non‐coding RNA molecules that have been linked with immunity through regulating/modulating gene expression. A role for these molecules in T ‐cell and B ‐cell development and function has been well established. An increasing body of literature now highlights the importance of specific mi RNA in dendritic cell ( DC ) development as well as their maturation process, antigen presentation capacity and cytokine release. Given the unique role of DC within the immune system, linking the innate and adaptive immune responses, understanding how specific mi RNA affect DC function is of importance for understanding disease. In this review we summarize recent developments in mi RNA and DC research, highlighting the requirement of mi RNA in DC lineage commitment from bone marrow progenitors and for the development of subsets such as plasmacytoid DC and conventional DC . In addition, we discuss how infections and tumours modulate mi RNA expression and consequently DC function.