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Regulation of immune responses by proton channels
Author(s) -
Capasso Melania
Publication year - 2014
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12326
Subject(s) - immune system , innate immune system , biology , identification (biology) , neuroscience , ion channel , proton , acquired immune system , voltage gated ion channel , microbiology and biotechnology , physics , genetics , receptor , botany , quantum mechanics
Summary The identification of the HVCN 1 gene, encoding the only mammalian voltage‐gated proton channel, prompted a number of studies on how proton channels affect cellular functions. As their expression is mainly restricted to immune cells, it is not surprising that proton channels regulate different aspects of immune responses. In this review, I will examine the current knowledge of voltage‐gated proton channels in both innate and adaptive responses and assess the remaining outstanding questions.