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Pemphigus vulgaris is characterized by low IgG reactivities to specific self‐antigens along with high IgG reactivity to desmoglein 3
Author(s) -
Fattal Ittai,
Rimer Jacob,
Shental Noam,
Molad Yair,
Gabrielli Armando,
Livneh Avi,
Sarig Ofer,
Goldberg Ilan,
Gafter Uzi,
Domany Eytan,
Cohen Irun R.
Publication year - 2014
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12316
Subject(s) - pemphigus vulgaris , autoantibody , immunology , desmoglein 3 , pemphigus , antigen , medicine , autoimmune disease , antibody , desmoglein , desmoglein 1
Summary Pemphigus vulgaris ( PV ) is an autoimmune skin disease, which has been characterized by IgG autoantibodies to desmoglein 3. Here we studied the antibody signatures of PV patients compared with healthy subjects and with patients with two other autoimmune diseases with skin manifestations (systemic lupus erythematosus and scleroderma), using an antigen microarray and informatics analysis. We now report a previously unobserved phenomenon – patients with PV , compared with the healthy subjects and the two other diseases, show a significant decrease in IgG autoantibodies to a specific set of self‐antigens. This novel finding demonstrates that an autoimmune disease may be associated with a loss of specific, healthy IgG autoantibodies and not only with a gain of specific, pathogenic IgG autoantibodies.