z-logo
Premium
Different subsets of natural killer T cells may vary in their roles in health and disease
Author(s) -
Kumar Vipin,
Delovitch Terry L.
Publication year - 2014
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12247
Subject(s) - natural killer t cell , t cell receptor , biology , immunology , immune system , antigen , cd1d , t cell , cd1 , acquired immune system , microbiology and biotechnology
Summary Natural killer T cells ( NKT ) can regulate innate and adaptive immune responses. Type I and type II NKT cell subsets recognize different lipid antigens presented by CD 1d, an MHC class‐I‐like molecule. Most type I NKT cells express a semi‐invariant T‐cell receptor ( TCR ), but a major subset of type II NKT cells reactive to a self antigen sulphatide use an oligoclonal TCR . Whereas TCR ‐ α dominates CD 1d‐lipid recognition by type I NKT cells, TCR ‐ α and TCR ‐ β contribute equally to CD 1d‐lipid recognition by type II NKT cells. These variable modes of NKT cell recognition of lipid– CD 1d complexes activate a host of cytokine‐dependent responses that can either exacerbate or protect from disease. Recent studies of chronic inflammatory and autoimmune diseases have led to a hypothesis that: (i) although type I NKT cells can promote pathogenic and regulatory responses, they are more frequently pathogenic, and (ii) type II NKT cells are predominantly inhibitory and protective from such responses and diseases. This review focuses on a further test of this hypothesis by the use of recently developed techniques, intravital imaging and mass cytometry, to analyse the molecular and cellular dynamics of type I and type II NKT cell antigen‐presenting cell motility, interaction, activation and immunoregulation that promote immune responses leading to health versus disease outcomes.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here