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Vitamin A and dendritic cell differentiation
Author(s) -
Beijer Marieke R.,
Kraal Georg,
Haan Joke M. M.
Publication year - 2014
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12228
Subject(s) - immune system , retinoic acid , spleen , biology , vitamin , dendritic cell , homing (biology) , integrin alpha m , microbiology and biotechnology , immunology , cellular differentiation , biochemistry , ecology , gene
Summary Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells ( DC ) depends on the presence of vitamin A. Recent studies indicate that also the differentiation of CD 11b + DC subsets in the mucosa as well as the spleen depend on vitamin A signalling. As CD 11b + DC subsets exert non‐redundant functions in anti‐bacterial and anti‐fungal immune responses, defects in CD 11b + DC differentiation will contribute to the clinical problems observed during vitamin A deficiency.