Vitamin A and dendritic cell differentiation | Zendy

Beijer Marieke R. | Zendy; Kraal Georg | Zendy; Haan Joke M. M. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Vitamin A and dendritic cell differentiation

Author(s) -

Beijer Marieke R.,

Kraal Georg,

Haan Joke M. M.

Publication year - 2014

Publication title -

immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.297

H-Index - 133

eISSN - 1365-2567

pISSN - 0019-2805

DOI - 10.1111/imm.12228

Subject(s) - immune system , retinoic acid , spleen , biology , vitamin , dendritic cell , homing (biology) , integrin alpha m , microbiology and biotechnology , immunology , cellular differentiation , biochemistry , ecology , gene

Summary Vitamin A and its active metabolite retinoic acid are essential for the development and function of many tissues including the immune system. The induction of mucosal homing receptors on T and B cells by mucosal dendritic cells ( DC ) depends on the presence of vitamin A. Recent studies indicate that also the differentiation of CD 11b + DC subsets in the mucosa as well as the spleen depend on vitamin A signalling. As CD 11b + DC subsets exert non‐redundant functions in anti‐bacterial and anti‐fungal immune responses, defects in CD 11b + DC differentiation will contribute to the clinical problems observed during vitamin A deficiency.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research