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Effect of age and maternal antibodies on the systemic and mucosal immune response after neonatal immunization in a porcine model
Author(s) -
GuzmanBautista Edgar R.,
GarciaRuiz Carlos E.,
GamaEspinosa Alicia L.,
RamirezEstudillo Carmen,
RojasGomez Oscar I.,
VegaLopez Marco A.
Publication year - 2014
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12222
Subject(s) - immune system , immunology , antibody , ovalbumin , saliva , antigen , immunization , biology , vaccination , immunity , immunoglobulin a , immunoglobulin g , biochemistry
Summary Newborn mammals are highly susceptible to respiratory infections. Although maternal antibodies ( M at A b) offer them some protection, they may also interfere with their systemic immune response to vaccination. However, the impact of M at A b on the neonatal mucosal immune response remains incompletely described. This study was performed to determine the effect of ovalbumin ( OVA ) ‐specific M at A b on the anti‐ OVA antibody response in sera, nasal secretions and saliva from specific pathogen‐free Vietnamese miniature piglets immunized at 7 or 14 days of age. Our results demonstrated that M at A b increased antigen‐specific I g A and I g G responses in sera, and transiently enhanced an early secretory I g A response in nasal secretions of piglets immunized at 7 days of age. In contrast, we detected a lower mucosal (nasal secretion and saliva) anti‐ OVA I g G response in piglets with M at A b immunized at 14 days of age, compared with piglets with no M at A b, suggesting a modulatory effect of antigen‐specific maternal factors on the isotype transfer to the mucosal immune exclusion system. In our porcine model, we demonstrated that passive maternal immunity positively modulated the systemic and nasal immune responses of animals immunized early in life. Our results, therefore, open the possibility of inducing systemic and respiratory mucosal immunity in the presence of M at A b through early vaccination.