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Emerging role of interleukin‐33 in autoimmune diseases
Author(s) -
Pei Cheng,
Barbour Mark,
FairlieClarke Karen J.,
Allan Debbie,
Mu Rong,
Jiang HuiRong
Publication year - 2014
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12174
Subject(s) - immunology , immune system , cytokine , inflammation , autoimmune disease , disease , interleukin 33 , autoimmunity , medicine , interleukin , biology , antibody , pathology
Summary Interleukin‐33 ( IL ‐33) is a member of the IL ‐1 cytokine family. It predominantly induces type 2 immune responses and thus is protective against atherosclerosis and nematode infections but contributes to allergic airway inflammation. Interleukin‐33 also plays a pivotal role in the development of many autoimmune diseases through mechanisms that are still not fully understood. In this review, we focus on the recent advances in understanding of the expression and function of IL ‐33 in some autoimmune disorders, aiming to provide insight into its potential role in disease development.