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Human dendritic cell subsets
Author(s) -
Collin Matthew,
McGovern Naomi,
Haniffa Muzlifah
Publication year - 2013
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12117
Subject(s) - immune system , biology , dendritic cell , context (archaeology) , immunology , immunity , antigen , microbiology and biotechnology , paleontology
Summary Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allowing many of these properties to be more fully understood in the context of human immunology.