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Regulators of chromatin state and transcription in CD 4 T ‐cell polarization
Author(s) -
Josefowicz Steven Z.
Publication year - 2013
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12115
Subject(s) - chromatin , transcription factor , microbiology and biotechnology , transcription (linguistics) , regulator , biology , transcription coregulator , dna , chromatin remodeling , genetics , gene , linguistics , philosophy
Summary Mature naive CD 4 T ‐cells possess the potential for an array of highly specialized functions, from inflammatory to potently suppressive. This potential is encoded in regulatory DNA elements and is fulfilled through modification of chromatin and selective activation by the collaborative function of diverse transcription factors in response to environmental cues. The mechanisms and strategies employed by transcription factors for the programming of CD 4 T ‐cell subsets will be discussed. In particular, the focus will be on co‐operative activity of environmental response factors in the initial activation of regulatory DNA elements and chromatin alteration, and the subsequent role of ‘master regulator’ transcription factors in defining the fidelity and environmental responsiveness of different CD 4 T ‐cell subsets.