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Transcription factors and CD 4 T cells seeking identity: masters, minions, setters and spikers
Author(s) -
Vahedi Golnaz,
Kanno Yuka,
Sartorelli Vittorio,
O'Shea John J.
Publication year - 2013
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12113
Subject(s) - enhancer , transcription factor , stat protein , transcription (linguistics) , biology , activator (genetics) , cytokine , signal transduction , microbiology and biotechnology , genetics , stat3 , gene , linguistics , philosophy
Summary Naive T cells differentiate and become distinct subsets in response to changes in the cytokine milieu. Such specialization arises through a complex and dynamic utilization of cis ‐regulatory enhancer elements. In this brief essay, we review recent findings on the relative contributions of sensors of the cytokine milieu, especially the signal transducer and activator of transcription family transcription factors, ‘master regulators’, and other transcription factors in the enhancer architecture of T cells. These findings provide new insights into how signal transduction impinges upon the genome.