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Rapid innate control of antigen abrogates adaptive immunity
Author(s) -
Pembroke Thomas P. I.,
Gallimore Awen M.,
Godkin Andrew
Publication year - 2013
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/imm.12048
Subject(s) - immunology , acquired immune system , innate immune system , antigen , immune system , biology , immunization , immunological memory , immunity , viral infection , virology , virus
Summary Natural killer ( NK ) cells provide an immediate first line of defence against viral infections. Memory responses, maintained by CD 4 + T cells, require exposure to viral antigen and provide long‐term protection against future infections. It is known that NK cells can promote the development of the adaptive response through cytokine production and cross‐talk with antigen‐presenting cells. In this paper however, we summarize a series of recent publications, in mouse models and for the first time in man, with the unifying message that rapid viral antigen control by the innate immune system limits antigen exposure to CD 4 + cells thereby abrogating the development of a memory response. We discuss the significant implication of these studies on viral treatment strategies and immunization models.