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T3 Toxicosis and its Relation to the Iodide Status in Singapore
Author(s) -
Yeo Peter P. B.,
Gwee H. M.,
Tan N. B.,
Ho C. L.,
Cheah J. S.,
Lee G. S.,
Lim P.,
Jacob E.,
Tan Y. T.,
Tambyah J. A.,
Tan B. Y.
Publication year - 1976
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/imj.1976.6.4.311
Subject(s) - medicine , iodide , iodine , thyroid function , thyroid function tests , thyroid , sephadex , endocrinology , gastroenterology , biochemistry , chemistry , enzyme , organic chemistry
Summary Baseline thyroid function tests (including total serum thyroxine iodide‐T 4 I, total serum tri‐iodothyronine T 3 as well as T 3 Sephadex Uptake Studies (T 3 U)) were determined in 82 normal Asian subjects. In addition, another group of normal volunteers (39) were assessed as regards serum and 24‐hour urinary iodide levels to gauge the iodide status of the community; the results were comparable to that of goitre‐free regions of the world. Having established the range of values of normal thyroid function tests, 103 consecutive clinically thyrotoxic patients (both new and relapsed cases) were similarly studied in an attempt to elucidate the magnitude of the problem of T 3 toxicosis, and its relation to the iodide status in Singapore. Only three clinically hyperthyroid patients were found to have normal PBI (protein‐bound iodine), T 4 I, T 3 U but raised T 3 levels. A detailed analysis and discussion of the data is presented. It is concluded that T 3 toxicosis is a rarity in Singapore.