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Low Density Lipoprotein Peptide Metabolism in Nephrotic Syndrome
Author(s) -
Scott P. J.,
White B. M.,
Winterbourn Christine C.,
Hurley P. J.
Publication year - 1970
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1970.19.1.1
Subject(s) - nephrosis , nephrotic syndrome , medicine , endocrinology , catabolism , lipoprotein , metabolism , chemistry , cholesterol
Summary Using human serum low density lipoprotein labelled in the peptide component with 131 I or 125 I, turnover studies were carried out in nine patients suffering from nephrotic syndrome with accompanying hyperlipoproteinaemia. Results were compared with data obtained previously in a group of normal subjects, and with similar information from patients whose hyperlipoproteinaemia was associated with syndromes other than nephrosis. Fractional catabolic rates were normal in the nine patients with nephrotic syndrome and in four patients with diabetes mellitus and hyperlipoproteinaemia. This pattern was similar to that previously described for patients with two forms of primary familial hyperlipoproteinaemia, but differed from the pattern reported for myxoedema in which hyperlipoproteinaemia was associated with a reduced fractional catabolic rate for low density lipoprotein peptide. In hypothyroidism the absolute catabolic rate was within the range observed in normal people, whereas in nephrosis and in primary or familial hyperlipoproteinaemia there was an increase in absolute turnover although the fractional rates were normal. From analysis of plasma decay curves it was concluded that in nephrotic syndrome, and in myxoedema, the proportion of the total miscible low density lipoprotein pool lying outside the plasma compartment was reduced.