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ACTIVE CHRONIC HEPATITIS WITH POSITIVE L.E. CELL TEST AND LUPUS NEPHRITIS
Author(s) -
FUNG W. P.,
CHEW B. K.,
TAN K. K.
Publication year - 1969
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1969.18.3.288
Subject(s) - medicine , lupus nephritis , jaundice , hepatitis , gastroenterology , renal biopsy , cirrhosis , liver biopsy , nephritis , immunology , acute tubular necrosis , biopsy , pathology , kidney , disease
SUMMARY A case of active chronic hepatitis with a positive L.E. cell phenomenon and terminal acute renal failure secondary to lupus nephritis is reported in a Chinese girl of 10 years of age. This patient presented initially with an acute hepatitis which was associated with hypergammaglobulinæmia, raised immuno‐globulin levels and evidence of renal involvement. Liver biopsy showed marked piecemeal necrosis with rosette formation, a picture of active chronic hepatitis. After seven months she developed acute renal failure, acute cardiac failure and severe anæmia. There was persistent jaundice and hepatomegaly. Tests for L.E. cells gave positive results on three separate occasions. She died in renal and liver failure. Necropsy material showed cirrhosis and the changes of lupus nephritis.