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AMILORIDE HYDROCHLORIDE, A HYPERCALCIURIC DIURETIC
Author(s) -
JOHNY K. V.,
LAWRENCE J. R.,
O'HALLORAN M. W.
Publication year - 1969
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1969.18.3.267
Subject(s) - hypercalciuria , diuretic , amiloride , endocrinology , calcium , potassium , urinary calcium , medicine , sodium , diuresis , excretion , chemistry , kidney , organic chemistry
SUMMARY Administration of amiloride hydrochloride, a new potassium‐sparing diuretic, to six healthy volunteers for seven days produced significant hypercalciuria. No consistent interrelationship between the urinary excretion of calcium and magnesium, potassium or phosphorus was demonstrable. Three subjects with marked hypercalciuria showed no significant correlation between urinary calcium and sodium excretion, whereas one with marked hypercalciuria and two others with moderate or no hypercalciuria showed a significant correlation. A direct influence on the renal tubular handling of calcium, perhaps augmented by sodium diuresis, is suggested as a possible explanation for this hypercalciuric effect.