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LONG‐TERM TREATMENT OF PORTAL‐SYSTEMIC ENCEPHALOPATHY WITH LACTULOSE
Author(s) -
MA M. H.,
McLEOD J. G.,
BLACKBURN C. R. B.
Publication year - 1969
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1969.18.2.117
Subject(s) - lactulose , medicine , hepatic encephalopathy , cirrhosis , decompensation , gastroenterology , encephalopathy , portal hypertension
SUMMARY Ten patients with chronic portal‐systemic encephalopathy have been treated with lactulose and dietary restriction of protein. The treatment was found to be effective in six cases for periods up to 12 months. Two patients with very advanced cirrhosis and hepatic decompensation failed to respond. Two other patients were intolerant of lactulose. It is concluded that lactulose is an effective drug in the treatment of chronic portal‐systemic encephalopathy, and is a useful substitute for neomycin.