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HYPONATRÆMIA AND RENOVASCULAR HYPERTENSION
Author(s) -
BONNIN J. MARK,
EDWARDS R. G.,
SCROOP G. C.,
SKINNER S. L.,
WHELAN R. F.
Publication year - 1968
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1968.17.4.315
Subject(s) - renovascular hypertension , medicine , renin–angiotensin system , phentolamine , plasma renin activity , nephrectomy , cardiology , endocrinology , kidney , blood pressure , stimulation
SUMMARY A case of traumatic renal artery thrombosis in which the patient developed the hyponatnemic hypertensive syndrome is described. Decreased vascular sensitivity to angiotensin, grossly elevated plasma renin levels, hypertension and hyponatræmia returned to normal after unilateral nephrectomy. Sequential renin and electrolyte studies indicated that this syndrome was caused by the pressor and natriuretic actions of high circulating levels of renin and angiotensin. No evidence could be found to support the suggestion that the high renin levels were secondary to sodium depletion. A positive result to a phentolamine test was recorded, leading to initial problems in diagnosis. The patient is normotensive and well three years after this episode.

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