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LIVER DISEASE IN PREGNANCY, WITH PARTICULAR EMPHASIS ON THE CHOLESTATIC SYNDROMES
Author(s) -
MISTILIS STEVEN P.
Publication year - 1968
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1968.17.3.248
Subject(s) - cholestasis , medicine , pregnancy , cholestasis of pregnancy , pathogenesis , disease , jaundice , differential diagnosis , liver function tests , liver disease , physiology , gastroenterology , bioinformatics , pathology , fetus , biology , genetics
Summary This review is primarily concerned with the ætiology, pathology, clinical features, differential diagnosis, pathogenesis and treatment of obstetric cholestasis and pruritus of pregnancy. The exact mechanism of the pruritus, jaundice and deranged biochemical state in these disorders is discussed in the light of advances in our understanding of bile salt metabolism and a recent and more acceptable concept of the pathogenesis of cholestasis. The incidence, ætiology and clinical features of cholestasis following oral contraceptives are outlined in detail, and the relationship of these changes to the cholestatic syndrome in the third trimester is discussed. Other hepatic disorders which appear to be related to pregnancy are also briefly reviewed. Biochemical derangements of hepatic function in pregnant women without underlying hepatic disease are considered in detail.