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INSULIN SENSITIVITY AND 131 I INSULIN METABOLISM IN JUVENILE‐TYPE DIABETICS
Author(s) -
MARTIN F. I. R.,
STOCKS A.E.
Publication year - 1967
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1967.16.4.289
Subject(s) - insulin , medicine , endocrinology , diabetes mellitus , heterologous , chemistry , biochemistry , gene
SUMMARY 1. The acute response of blood glucose levels to insulin, and the half‐time of disappearance and degree of protein binding of 131 I‐labelled insulin as determined by electrophoresis, have been studied in 43 insulin‐dependent diabetics with disease of long duration. Of the patients studied, 21 (50%) had a blood glucose response to insulin which was within normal limits. The remaining 22 patients were insensitive, showing both a delay in response and a significantly decreased rate of fall of blood glucose levels after insulin administration. 2. A weak correlation was observed between insulin sensitivity and both the half‐time of disappearance and the degree of protein binding of radioactive insulin, but no relationship was found between any of these parameters and the somatic index, the degree of “brittleness” of individual patients, the dose of insulin required or the duration of diabetes. 3. It is proposed that there may be two populations of juvenile‐type diabetics, one sensitive and one insensitive to the acute effects of insulin, which cannot adequately be explained by the effects of heterologous antibody formation on injected insulin.