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RELATIONSHIP BETWEEN S‐T SEGMENT DEPRESSION DURING EXERCISE AND INCREMENTS IN THE URINARY EXCRETION OF 3‐METHOXY 4‐HYDROXY MANDELIC ACID IN MEN WITH CORONARY HEART DISEASE
Author(s) -
NESTEL P. J.,
HAMMOND JUDY
Publication year - 1967
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1967.16.2.151
Subject(s) - excretion , heart rate , metabolite , catecholamine , medicine , endocrinology , coronary heart disease , urinary system , physical exercise , mandelic acid , urine , cardiology , sympathetic nervous system , blood pressure , chemistry , organic chemistry
Summary The urinary excretion of the major catecholamine metabolite, 3‐methoxy 4‐hydroxy mandelic acid (VMA) was measured in subjects with coronary heart disease before and after an exercise study. The electrocardiographic changes induced by exercise were measured continuously before and throughout exercise. The following findings were observed : The magnitude of the S‐T segment change was significantly related to the post‐exercise increment in urinary VMA excretion. The magnitude of the S‐T segment change was also significantly related to the rise in heart rate. 3. The rise in heart rate was significantly related to the increment in the urinary excretion of VMA. Although the mechanisms responsible for these findings have not been established, we conclude that an association exists between sympathetic nervous responsiveness during exercise and the development of myocardial ischxmia.