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“ A.T. 10 “ AND DIHYDROTACHYSTEROL
Author(s) -
PARFITT A. M.
Publication year - 1967
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1967.16.2.114
Subject(s) - hypoparathyroidism , hypercalcaemia , medicine , capsule , endocrinology , calcium , biology , botany
Summary The effect of pure dihydrotachysterol (D.H.T.) was compared with that of the old “ A.T. 10 ” in eight patients with hypoparathyroidism, and it was found that the “ A.T. 10 ” available in 1963–1964 was equivalent in therapeutic activity to 0.1 mg. of D.H.T. per capsule (or 0.2 mg. of D.H.T. per millilitre). It is concluded that the new “ A.T. 10 ” (containing 0.25 mg. of D.H.T. per millilitre) is 25% stronger than the old, and that patients whose therapy is changed to the new preparation in the same dose (by volume) may occasionally develop hypercalcaemia as a result. The history of the various changes in the methods of assay of “ A.T. 10 ” is reviewed and the reasons why they were all fallacious are explained. As judged by reported maintenance doses, the “ A.T. 10 ” available in 1963–1964 was only one‐third as potent in the treatment of hypoparathyroidism as that available in 1934–1942.