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CYTOGENETIC STUDIES IN CHRONIC GRANULOCYTIC LEUKÆMIA
Author(s) -
DOUGAN L.,
ONESTI P.,
WOODLIFF H. J.
Publication year - 1967
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1967.16.1.52
Subject(s) - chronic granulocytic leukemia , chromosome , myeloproliferative disorders , philadelphia chromosome , cytogenetics , karyotype , medicine , pathology , biology , immunology , leukemia , genetics , chromosomal translocation , gene
Summary A review of the literature shows that the Philadelphia (Ph 1 ) chromosome is present in cells from a majority of patients with chronic granulocytic leukæmia, including 19 presented here. An adequate explanation has been found for the failure to demonstrate the Ph 1 chromosome in all but four cases in the literature. The Ph 1 chromosome has only rarely been reported in other myeloproliferative disorders, and never in other conditions. The positivity in the myeloproliferative disorders is discussed and the probability that the few reported cases are atypical examples of chronic granulocytic leukæmia is considered. The diagnostic value of cytogenetic studies in prognosis and therapy is considered. The conclusion is reached that such studies are of definite but limited value. Theoretical implications of the Ph 1 chromosome are discussed with particular reference to the stem cell, leucopoiesis and chromosome 21, the inter‐relationship of the myeloproliferative disorders and the pathogenesis of chronic granulocytic leukæmia.