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THE MEASUREMENT OF ANDROGEN PRODUCTION IN NORMAL SUBJECTS
Author(s) -
HUDSON BRYAN,
DULMANIS AUSMA,
COGHLAN JOHN P.,
WNTOUR MARELYN
Publication year - 1966
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1966.15.3.236
Subject(s) - testosterone (patch) , urine , endocrinology , medicine , urinary system , androgen , isotope dilution , production rate , chemistry , hormone , chromatography , mass spectrometry , industrial engineering , engineering
SUMMARY The discovery of testosterone in urine and the development of methods for its measurement in plasma and urine have provided fresh approaches for the evaluation of androgen function in man. Production rates of testosterone have been measured in normal men and women by means of the principle of isotope dilution. The specific activity of urinary testosterone is measured after the administration of a tracer dose of isotopically labelled testosterone. Production rates have also been estimated by measuring the concentration of testosterone in plasma and its rate of clearance from plasma, the product of these two values being the blood production rate. In 14 males blood and urinary production rates were not significantly different, but in females the blood production rates were significantly lower than those determined from the specific activity of urinary testosterone. The possible reasons for this discrepancy are analysed.