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A CHROMOSOME ABNORMALITY ASSOCIATED WITH MACROGLOBULINÆMIA
Author(s) -
BLAKE M. N.
Publication year - 1966
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1966.15.2.162
Subject(s) - chromosome , centromere , abnormality , peripheral blood , biology , long arm , pathology , chromosome abnormality , cryoglobulin , genetics , karyotype , microbiology and biotechnology , immunology , medicine , cryoglobulinemia , hepatitis c virus , virus , psychiatry , gene
SUMMARY Examination of serum from an adult male patient with lymphosarcoma showed the presence of two macroglobulins and a large amount of cryoglobulin. Chromosome studies on peripheral blood leucocytes, cultured prior to any treatment, showed that of 110 cells analysed, 21 contained an extra chromosome of abnormal morphology. All the abnormal chromosomes were large; 18 showed a submedian centromere, the remaining three a median centromere. A biometric comparison of the arm lengths of these abnormal chromosomes with the corresponding measurements for the 1–3 and 4–5 groups, and the four longest chromosomes of the X+ (6–12) group, suggests that the abnormal chromosome was not related to the normal number 2 pair, as previously suggested by reports of similar cases.