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RENAL LESIONS IN EXPERIMENTAL PLUMBISM AND THEIR CLINICAL IMPLICATIONS
Author(s) -
TANGE, D.,
HAYWARD NANCY,
BREMNER D. A.
Publication year - 1965
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1965.14.1.49
Subject(s) - lead acetate , lead poisoning , kidney , medicine , renal cortex , pathology , nephrectomy , degeneration (medical) , disease , physiology , toxicity , psychiatry
Summary Administration of lead acetate to rats for long periods is associated with changes in the cells of the convoluted tubules, especially those in the deeper portions of the renal cortex. These changes comprise dilatation of the affected tubules, degeneration, death and subsequently regeneration of individual cells, nuclear inclusions, and atypical mononuclear, giant tubule cells. Gross changes in renal architecture are not produced by administration of lead acetate alone. Administration of lead acetate followed by unilateral nephrectomy is associated with the appearance of foci of scarring in the remaining kidney in a proportion of animals. These foci may be widespread. In the present study the factors determining presence or absence of scarring could not be defined. Kidneys damaged by lead acetate are no more susceptible than normal kidneys to damage from intravenous injection of Escherichia coli . These experimental results may help to explain the frequency of chronic renal disease following lead poisoning in infancy and childhood and its rarity in industrial lead poisoning.