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TRANSIENT ALTERATIONS IN EXCRETION OF UREA WITH DIURESIS IN MAN
Author(s) -
HAAS L. F.,
HOLDAWAY I. M.,
ROBINSON J. R.
Publication year - 1965
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1965.14.1.40
Subject(s) - urea , diuresis , chemistry , excretion , endocrinology , urine , diuretic , medicine , sodium , excretory system , kidney , natriuresis , renal function , biochemistry , organic chemistry
Summary Rates of excretion of urea were determined in two young men during water diuresis and during osmotic diuresis with sodium chloride and with urea. At the onset of water diuresis or of osmotic diuresis with sodium chloride, there was a large, but transient, increase in the rate of excretion of urea, which reached its peak about an hour before the peak of diuresis and then fell again while the urinary minute volume continued to increase. The transient increase in excretory rate suggested that urea previously stored in the kidney was washed out when the urinary concentration fell, but too much was washed out to have been contained in concentrated urine in the renal‐tract dead space. The greater part of this urea probably diffused out from an intrarenal store when the urinary concentration fell. When urea was used as the diuretic, the concentration of urea in the urine did not fall, and the transient excretion of stored urea did not occur. The intrarenal store could have been accommodated in a volume of the same order as the subjects' medullary fluid. Urea appears to be accumulated in the human kidney, as it has been found to be accumulated by a countercurrent mechanism in the kidneys of other mammals.