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RESIN UPTAKE OF 131 I‐LABELLED TRIIODOTHYRONINE AS A TEST OF THYROID FUNCTION
Author(s) -
TAYLOR KATHLEEN,
WINIKOFF DORA,
DAVIES WANDA
Publication year - 1964
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1964.13.3.240
Subject(s) - triiodothyronine , euthyroid , amberlite , thyroid function tests , ion exchange resin , chemistry , thyroid function , endocrinology , medicine , iodine , thyroid , diiodotyrosine , inorganic chemistry , organic chemistry , adsorption
Summary A simple in‐vitro test of thyroid function based on the uptake of 131 I‐labelled‐l‐triiodothyronine (T 3 ) by an anion exchange resin is described. Aliquots of serum equilibrated with T 3 are incubated with “Amberlite” resin; 24·7 % to 36 % of the T 3 is taken up by the resin in the euthyroid state, in hyperthyroidism the figure is 34·5 % to 55%, and in hypothyroidism it is 16·5 % to 26%. In pregnancy the resin uptake is 15·5 % to 26%. Studies have been made on variations in technique. A protein‐bound iodine (P.B.I.) estimation is performed on all patients investigated, including those receiving treatment for disorders of thyroid function. Results of both tests are compared.