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THE EFFECT OF ASPIRIN AND PHENACETIN ON ASCENDING INFECTION IN THE RAT KIDNEY
Author(s) -
DAWBORN J. K.,
KINCAID-SMITH PRISCILLA,
MCLAREN JANET
Publication year - 1964
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1964.13.3.217
Subject(s) - phenacetin , aspirin , kidney , medicine , atrophy , lesion , urinary system , physiology , pathology
Summary Four groups of rats were fed on diets containing different amounts of aspirin and phenacetin. After 15 weeks on these diets, half the rats in each group were given an intravesical injection of Escherichia coli, and this was repeated three weeks later. All the rats were killed at the end of five months and the kidneys were examined. No difference was noted between the kidneys of control rats and those fed on drugs, although all groups showed some areas of inflammatory cell infiltration and atrophy of renal tubules similar to those said to be caused by phenacetin. The severity and incidence of infection in those rats subjected to bacterial infection was less in phenacetin‐fed rats than in controls. The existence of a specific renal lesion due to phenacetin remains uncertain. The correct experimental conditions have not yet been found which produce renal lesions in animals similar to those attributed to phenacetin in man. Careful clinical studies rather than laboratory experiments appear to be most likely to throw further light on the role of phenacetin in renal disease in man.