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ORAL I 131 ‐TRIOLEIN TOLERANCE CURVES IN NORMAL, ATHEROSCLEROTIC AND HYPERLIPÆMIC SUBJECTS
Author(s) -
PRIOR I. A. M.,
ARMSTRONG W. E.,
CARR A. H.
Publication year - 1963
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1963.12.3.208
Subject(s) - triolein , medicine , gastroenterology , oral administration , significant difference , endocrinology , chemistry , biochemistry , lipase , enzyme
SUMMARY The levels of whole blood and trichloracetic precipitable radioactivity have been studied after the oral administration of I 131 ‐labelled triolein in 30 atherosclerotic, seven hyperlipæmic and 20 apparently normal subjects. A very abnormal pattern with high peak levels and persistently high levels at 24, 48 and 72 hours has been found in the hyperlipæmic subjects. The mean levels were significantly higher in the atherosclerotic as compared with the normal subjects, but considerable overlap was present between the groups, and the test clearly lacks sensitivity in detecting all subjects with manifest atherosclerosis. Estimation of the lipæmia clearance rate showed no significant difference in the atherosclerotic as compared with the control group, but the figure was significantly slower in the hyperlipæmic group in the first 24 hours. The effect of anticoagulants given by mouth was observed in eight subjects, and repeat observations made while they were on and off anticoagulants failed to confirm any significant effect from the anticoagulants on mean levels or on rate of clearing. The limitations and future value of the oral I 131 triolein test are discussed.