Premium
MACROGLOBULINÆMIA WITH CHROMOSOMAL ANOMALY
Author(s) -
FERGUSON JEAN,
MACKAY IAN R.
Publication year - 1963
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1963.12.3.197
Subject(s) - biology , somatic cell , karyotype , chromosome , macroglobulin , genetics , pathological , pathology , immunology , microbiology and biotechnology , medicine , gene
SUMMARY In one case of Waldenström's macroglobulinæmia with myelosclerosis, approximately half the blood cells had a normal chromosome complement of 46 and the remainder contained a large extra “W” chromosome; the chromosomes of the skin cells were normal. The chromosomes of the blood cells of two other patients were normal. Chromosomal anomalies may reflect the occurrence of somatic mutation in cases of macroglobulinæmia; but whether this is an essential cellular genetic lesion for pathological macroglobulin synthesis is still undetermined.