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LACTIC DEHYDROGENASE ACTIVITY OF GASTRIC JUICE OF NORMAL SUBJECTS AND OF PATIENTS WITH GASTRIC ULCER, DUODENAL ULCER, GASTRIC CARCINOMA AND PERNICIOUS ANÆMIA: A PRELIMINARY REPORT
Author(s) -
MACOUN MARY L.,
BUILDER E.,
PIPER D. W.
Publication year - 1963
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1963.12.2.160
Subject(s) - gastroenterology , gastric carcinoma , medicine , lactic dehydrogenase , stomach , duodenal ulcer , helicobacter pylori , cancer , enzyme , chemistry , biochemistry
SUMMARY Lactic dehydrogenase (LDH) activity is not found in acid gastric juice, because the enzyme is inactivated at pH levels below 6. In the study reported, the pH of the gastric contents was maintained above 7 by intragastric neutralization. LDH activity was found in the gastric juice of seven of the nine control patients, of 13 of the 17 gastric ulcer patients, of five of the six duodenal ulcer patients, and of all the five gastric carcinoma patients ; activity was significantly increased in the gastric juice of gastric carcinoma patients when the latter group was compared with the control and gastric‐ulcer groups. There was no correlation between the serum and salivary LDH activity and the LDH activity in gastric juice.