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EXPERIMENTAL FIBRINOLYSIS
Author(s) -
FANTL P.
Publication year - 1963
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1963.12.2.135
Subject(s) - streptokinase , fibrinolysis , fibrinogen , plasmin , fibrin , chemistry , lysis , pharmacology , medicine , chromatography , biochemistry , enzyme , immunology , myocardial infarction
SUMMARY The commercial preparation “Thrombolysin” intended for intravenous infusion in the treatment of thrombosis has properties which can be imitated by a mixture prepared from streptokinase as the major and plasmin as a minor component. Such mixtures have fibrinolytic activity which increases with concentration. This is in contrast to streptokinase, which shows inhibitory properties at higher concentrations. Intravenous infusions of “Thrombolysin” were well tolerated. According to the amount injected, a corresponding decrease in blood plasminogen level occurred. In the dosage recommended for injection, no influence on prothrombin, fibrinogen or other plasma proteins was detected. Plasma taken several minutes after infusion of “Thrombolysin” no longer showed proteolytic activity. Adequate amounts of streptokinase added during clot formation in vitro produced short lysis time of fibrin, but streptokinase added after clot formation showed considerably less activity.