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NEUTROPHIL ALKALINE PHOSPHATASE
Author(s) -
WYLLIE R. G.
Publication year - 1962
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1962.11.2.118
Subject(s) - alkaline phosphatase , medicine , inflammation , gastroenterology , dyscrasia , lesion , immunology , pathology , enzyme , biology , bone marrow , biochemistry , plasma cell
Summary Neutrophil alkaline phosphatase (N.A.P.) levels were studied in 665 patients. In 511 patients, 24 hours after the onset of acute inflammation, the N.A.P. level was proportional to the extent and severity of the lesion. In 20 patients unexplained weak N.A.P. responses were observed. In 132 patients with a wide variety of non‐inflammatory diseases (excluding infarction, liver disease and blood dyscrasias), N.A.P. levels were normal. In two patients, raised N.A.P. levels occurred without demonstrable cause. It is concluded that N.A.P. levels reflect the progress of acute inflammation and can be of value in diagnosis.