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LEUCOCYTE LIPID METABOLISM IN MYELOPROLIFERATIVE STATES
Author(s) -
KIDSON CHEV
Publication year - 1962
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1962.11.1.50
Subject(s) - lipid metabolism , in vitro , chemistry , biochemistry , metabolism , myeloproliferative disorders , endocrinology , biology , medicine , immunology
Summary Lipid synthesis in human leucocytes was examined in vitro in blood from patients with myeloproliferative states and from normal controls, acetate being used as substrate. The incorporation of acetate‐1‐C 14 was measured in total lipids, neutral lipids and phospholipids of the leucocytes and plasma. There was a low rate of total lipid synthesis in polycythæmia vera, but the relative rates of incorporation of radioactivity into lipid fractions were normal. Lipid synthesis in myelosclerosis was similar to that in the controls with the exception of one case, in which a very high rate was observed, and in which incorporation of radioactivity into phospholipids was disproportionately increased. These results are discussed in relation to cell age and to leucocyte lipid synthesis in myeloid leukæmia.