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FAMILIAL ENDOCRINE ADENOMATOSIS WITH ULCEROGENIC TUMOUR OF THE PANCREAS
Author(s) -
SAINT E. G.,
FINLAY-JONES R.,
STEWART H. H.
Publication year - 1961
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1961.10.4.308
Subject(s) - chromophobe cell , adenoma , nesidioblastosis , medicine , pancreas , hyperplasia , multiple endocrine neoplasia , pituitary adenoma , pathology , endocrine system , autopsy , parathyroid neoplasm , gastroenterology , parathyroid adenoma , insulinoma , clear cell , carcinoma , hormone , biology , biochemistry , gene
Summary A further instance of the syndrome of familial multiple endocrine adenomatosis is described, an unusual feature being the occurrence in two generations of the less common non‐beta‐cell adenoma of the pancreatic islets, causing in the daughter typical clinical manifestations of the Zollinger‐Ellison syndrome—primary jejunal ulceration and recurrent marginal ulceration, requiring total gastrectomy and pancreatectomy. This patient has also a pituitary tumour, the evidence pointing to a chromophobe adenoma, and may possibly have parathyroid hyperplasia or adenoma. The father of the patient was shown at autopsy to have parathyroid adenomas, a pituitary chromophobe adenoma, adrenal cortical hyperplasia and a pancreatic islet‐cell adenoma morphologically resembling most closely that seen in his surviving issue.