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LIPID SYNTHESIS IN HUMAN LEUCOCYTES IN ACUTE LEUKÆMIA
Author(s) -
KIDSON CHEV
Publication year - 1961
Publication title -
australasian annals of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0571-9283
DOI - 10.1111/imj.1961.10.4.282
Subject(s) - phospholipid , in vitro , chemistry , myeloid , biochemistry , biology , medicine , immunology , membrane
SUMMARY Lipid synthesis in human leucocytes was examined in vitro in blood from patients with acute leukæmia and from normal controls, acetate being used as substrate. The incorporation of acetate‐1‐C 14 was measured in total lipids, neutral lipids and phospholipids of the leucocytes and plasma. Both morphological types of acute leukæmia revealed trends away from the normal rates of total lipid synthesis, the rates being high in acute myeloid leukæmia and low in acute lymphatic leukæmia. Fractional lipid synthesis was similar to the normal in acute lymphatic leukæmia, but in the cells of acute myeloid leukæmia proportionally more radioactivity was incorporated into the phospholipid fraction. This difference was not reflected in the plasma‐phospholipid fraction. The changes in leucocyte lipid synthesis are discussed in relation to the mixed‐cell populations involved and to the question of cell age.